Piperacillin + Tazobactam; Chemical name, Molecular Formula, Molar mass, Chemical Structure

Описание: Piperacillin + Tazobactam is a combination antibiotic therapy widely used in hospitals. Piperacillin is a broad‑spectrum ureidopenicillin, while tazobactam is a β‑lactamase inhibitor. Together, they extend coverage against resistant Gram‑negative and Gram‑positive bacteria.

🔬 Chemical Details
Piperacillin
Chemical Name (IUPAC):
(2S,5R,6R)-6-[[(2R)-2-(4-ethyl-2,3-dioxopiperazine-1-carbonyl)piperazin-1-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Molecular Formula: C₂₃H₂₇N₅O₇S

Molar Mass: 517.55 g/mol

Structure:

Penicillin nucleus (β‑lactam fused to thiazolidine).

Ureidopenicillin side chain with a piperazine ring, giving broad Gram‑negative activity.

Carboxylic acid group for solubility.

Tazobactam
Chemical Name (IUPAC):
(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 1,1-dioxide

Molecular Formula: C₁₀H₁₂N₄O₅S

Molar Mass: 300.29 g/mol

Structure:

β‑lactam ring with a sulfone group.

Triazole substituent.

Functions as a suicide inhibitor of β‑lactamase enzymes.

🧩 Combination Mechanism
Piperacillin: Inhibits bacterial cell wall synthesis by binding to penicillin‑binding proteins (PBPs).

Tazobactam: Protects piperacillin from enzymatic degradation by β‑lactamases, restoring activity against resistant organisms.

Clinical Use: Severe infections (intra‑abdominal, respiratory, urinary tract, skin/soft tissue, sepsis), especially when resistant Gram‑negative bacteria are suspected

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