Ticarcillin + Clavulanic acid; Chemical name, Molecular Formula, Molar mass, Chemical Structure
Автор: Sokoto Pharmacology
Загружено: 2026-02-16
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🔬 Chemical Details
Ticarcillin
Chemical name (IUPAC):
(2S,5R,6R)-6-
\[(carboxyphenyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
\[3.2.0]heptane-2-carboxylic acid
Molecular formula:
C₁₅H₁₆N₂O₆S
Molar mass:
≈ 384.37 g/mol
Structure description:
A β-lactam ring fused to a thiazolidine ring (typical of penicillins).
A carboxyphenyl side chain that broadens antibacterial spectrum.
Multiple stereocenters ensuring proper binding to bacterial enzymes.
Clavulanic acid
Chemical name (IUPAC):
(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo
\[3.2.0]heptane-2-carboxylic acid
Molecular formula:
C₈H₉NO₅
Molar mass:
≈ 199.16 g/mol
Structure description:
A β-lactam ring fused to an oxazolidine ring.
A hydroxyethylidene substituent at position 3.
Functions as a β-lactamase inhibitor, protecting ticarcillin from enzymatic degradation.
⚗️ Combination Significance
Ticarcillin: A broad-spectrum penicillin effective against Gram-negative bacteria.
Clavulanic acid: Prevents bacterial β-lactamases from breaking down ticarcillin.
Together: The combination extends antibacterial activity and is used clinically for resistant infections
#Ticarcillin #Clavulanicacid
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