Lecture On Glycine Metabolism & Specialized Products: Heme, Creatine, and Glutathione | MBBS

Описание: In this detailed session for the MBBS 2025-2026 batch, we explore the unique chemistry, synthesis, and metabolic pathways of Glycine—the simplest yet one of the most versatile amino acids. This video is an essential resource for medical students preparing for biochemistry exams and clinical correlations.

Key Topics Covered in This Video:

Chemistry of Glycine: Why it is the only optically inactive amino acid and its role in compact protein structures like Collagen [00:00] & [04:29].

Synthesis & Degradation: Five major sources of Glycine (Serine, Threonine, Glyoxylate, etc.) and its classification as a glucogenic amino acid [06:01] & [08:32].

One-Carbon Metabolism: Glycine’s critical role in the one-carbon pool via N5, N10-methylene tetrahydrofolate [03:26] & [26:05].

The Glycine Cleavage System (GCS): A deep dive into the multi-enzyme complex (P, T, L, and H proteins) and its importance as the major catabolic pathway [18:44] & [21:26].

Specialized Products from Glycine:

Heme Synthesis: Glycine as the precursor for ALA [05:08] & [36:24].

Creatine & Creatinine: The pathway involving Kidney, Pancreas, and Liver to fuel muscle contraction [09:34] & [27:02].

Purine Nucleotides: Contribution to the C4, C5, and N7 positions of the purine ring [09:43] & [37:18].

Glutathione: Its role in maintaining RBC membrane integrity and redox potential [10:41] & [38:17].

Bile Salts: Conjugation with Cholic acid to form Glycocholic acid [11:04] & [41:38].

Metabolic Disorders: * Non-ketotic Hyperglycinemia: Defects in the Glycine Cleavage System [45:42].

Primary Hyperoxaluria: Protein targeting defects leading to Oxalate Stones (Nephrolithiasis) [48:11] & [50:43].

Exam Preparation Tips:

Short Note Alert: One-Carbon Metabolism [03:26].

Clinical Correlation: Why high creatinine levels indicate renal dysfunction [35:10].

Anatomical Tip: Why every third amino acid in collagen must be Glycine [04:39].


SANTINIKETAN MEDICAL COLLEGE & HOSPITAL
Real Classroom Demonstration/Lecture
On: BIOCHEMISTRY by Dr. Biswajit Saha
(MBBS Batch: 2025-26)
Conducted on: 09-01-26