Lecture On Hemoglobin: Structure, Synthesis & Physiological Functions | MBBS

Описание: This session provides a comprehensive breakdown of the structural, biochemical, and functional aspects of hemoglobin, essential for every first-year medical student.

Learn about the intricate balance between heme and globin, the specific genes on Chromosomes 11 and 16, and how the body maintains oxygen delivery through cooperative binding and chemical buffering.

Key Topics & Timestamps:

Introduction to Hemoglobin: Defining the primary role of Hemoglobin in carrying oxygen and carbon dioxide [00:40].

Chemical Structure: * Heme: The role of Ferrous (Fe2+) iron and the structure of Pyrole rings and Porphyrins [02:18].

Globin: Analyzing alpha, beta, gamma, and delta polypeptide chains [03:26].

Hemoglobin Variants: Differentiating between Adult Hemoglobin (HbA, HbA2) and Fetal Hemoglobin (HbF) [13:08].

Physiological Functions: * Oxygen Carriage: The mechanism of cooperative binding and the sigmoid oxygen-dissociation curve [10:21].

Carbon Dioxide Transport: Formation of Carbaminohemoglobin [40:45].

Buffering Action: How Histidine residues maintain blood pH [41:54].

Blood Flow Regulation: The role of Nitric Oxide (NO) in vasodilation [46:06].

Hemoglobin Synthesis: * Pathway: From Succinyl CoA + Glycine to Delta-ALA (The rate-limiting step) [18:28].

Site of Synthesis: Linkage with Erythropoiesis stages (Intermediate Normoblast) [19:50].

Clinical Correlations: Differentiating between Globin and Globulin, and understanding Cyanosis (Reduced Hemoglobin) [16:16].


SANTINIKETAN MEDICAL COLLEGE & HOSPITAL
Real Classroom Demonstration/Lecture
On: PHYSIOLOGY by Dr. Akash Ghosh Roy
(MBBS Batch: 2025-26)
Conducted on: 13-01-26