May–Hegglin Anomaly | Hematological Diseases | Giant Platelets & Döhle-Like Bodies | BMLS

Описание: 🩸 May–Hegglin Anomaly | Hematological Diseases | Giant Platelets & Döhle-Like Bodies | BMLS

👩‍⚕️👨‍⚕️ BMLS Students – Important Rare Hematological Disorder!
In this video, we explain May–Hegglin Anomaly (MHA), a rare inherited platelet disorder characterized by giant platelets, thrombocytopenia, and Döhle-like inclusion bodies in neutrophils. This topic is highly important for hematology theory, practicals & viva.

🔬 What is May–Hegglin Anomaly?

🔹 A rare autosomal dominant hematological disorder
🔹 Belongs to MYH9-related disorders
🔹 Affects platelets and neutrophils

🧬 Etiology / Cause:

📌 Mutation in MYH9 gene
📌 Abnormal myosin heavy chain
📌 Leads to defective platelet formation

🩸 Key Features of May–Hegglin Anomaly:

✔ Giant platelets 🟣
✔ Thrombocytopenia (↓ platelet count)
✔ Döhle-like bodies in neutrophils 🔵
✔ Usually normal bleeding time
✔ Often asymptomatic or mild bleeding

🔍 Peripheral Blood Smear Findings:

🧫 Platelets → Large / giant platelets
🧫 Neutrophils → Pale blue Döhle-like inclusions
🧫 RBCs → Usually normal

📊 Laboratory Findings:

📌 Decreased platelet count
📌 Normal platelet function tests
📌 Normal PT & APTT
📌 Peripheral smear is diagnostic ⭐

⚠️ Clinical Features:

🔹 Often asymptomatic
🔹 Mild bleeding tendency
🔹 Easy bruising
🔹 Epistaxis (rare)



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🧠 Differential Diagnosis:

❌ Immune thrombocytopenic purpura (ITP)
❌ Bernard–Soulier syndrome
❌ Other giant platelet disorders

🎯 Why is May–Hegglin Anomaly Important?

✔ Asked in Hematological diseases – BMLS
✔ Important peripheral smear diagnosis
✔ Frequently confused with ITP in exams
✔ Viva favorite topic 🔥

👥 Who Should Watch This Video?

👩‍🔬 BMLS Students
👨‍🔬 BMLT / DMLT Students
🎓 Allied Health Science Students
🩺 Hematology Learners

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