Lithium vs. Antipsychotics: The Rise, Fall, and Rise Again of Lithium

Описание: Explore the journey of lithium, a game-changer in the late 1940s, as it transformed the treatment landscape for bipolar disorder. Join Dr. Tracey Marks, a dedicated psychiatrist, in this deep dive into the historical prominence of lithium, its subsequent decline in the wake of second-generation antipsychotics, and the compelling reasons why it might be time for a reevaluation. Delve into the intricacies of lithium's usage, including its narrow therapeutic window, monitoring requirements, and the benefits it offers at the cellular level. As we examine the potential side effects, organ impacts, and compare it with modern antipsychotics, we'll shed light on lithium's unparalleled advantages like its anti-suicidal properties, circadian rhythm stabilization, anti-aging effects, and more. Whether you're newly diagnosed with bipolar disorder or looking for a comprehensive understanding of treatment options, this video promises to be an enlightening exploration of a once-golden treatment. For additional insights into bipolar disorder classifications and medication effects, be sure to check out these two videos.

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REFERENCES:
Post RM. The New News about Lithium: An Underutilized Treatment in the United States. Neuropsychopharmacology. 2018;43(5):1174-1179. doi:10.1038/npp.2017.238

Mertens, Jerome et al. “Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder.” Nature vol. 527,7576 (2015): 95-9. doi:10.1038/nature15526

Ratheesh, A et al. “A systematic review of interventions in the early course of bipolar disorder I or II: a report of the International Society for Bipolar Disorders Taskforce on early intervention.” International journal of bipolar disorders vol. 11,1 1. 3 Jan. 2023, doi:10.1186/s40345-022-00275-3

Balan, Estelle et al. “Physical Activity and Nutrition: Two Promising Strategies for Telomere Maintenance?.” Nutrients vol. 10,12 1942. 7 Dec. 2018, doi:10.3390/nu10121942

Joseph, Boney et al. “Long-Term Lithium Therapy and Thyroid Disorders in Bipolar Disorder: A Historical Cohort Study.” Brain sciences vol. 13,1 133. 12 Jan. 2023, doi:10.3390/brainsci13010133

Lundberg, Martin et al. “Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder.” Frontiers in psychiatry vol. 11 586083. 29 Sep. 2020, doi:10.3389/fpsyt.2020.586083


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