Targeted cancer therapy: choosing the right assay to assess PARP inhibitors
Автор: BPS Bioscience
Загружено: 2023-01-06
Просмотров: 629
Описание:
Poly-ADP Ribose Polymerase(PARP) is a family of 17 proteins involved in a wide range of biological functions: repair of DNA damage, genome stability, chromatin remodeling, mitotic spindle assembly, regulation of RNA turnover and of gene expression, and DNA methylation. PARP enzymes catalyze the ADP-ribosylation of proteins. PARP1 and PARP2 are mostly involved in DNA repair, and it has been shown that PARP1/2 inhibitors specifically kill tumor cells in which another DNA repair pathway is not functional due to a genetic mutation or to concomitant inhibition. Whether studying PARP enzymatic activity, PARP1/2 trapping to DNA, or looking to eliminate the protein using a molecular glue, it is critical to understand the principles behind each type of assay and the advantages or drawbacks of various assay formats.
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