Development of a Cell-Based Reporter Assay for Measuring ADAR1 Editing Activity for Drug Discovery
Автор: BPS Bioscience
Загружено: 2024-05-22
Просмотров: 583
Описание:
Adenosine Deaminase Acting on RNA (ADAR) enzymes perform adenosine to inosine base editing in RNA, particularly targeting adenosines located within a specific double-stranded stem-loop motif. ADAR1 plays important roles in inflammation, autoimmune diseases, and cancer, and represents an attractive target for therapeutic development. BPS Bioscience has developed and validated high-throughput, cell-based assays for measuring ADAR1 editing activity. This webinar will describe the principle of these cell-based assays, present data, and discuss the scientific applications of the cell lines.
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