The Promise of Senolytics to Treat Aging with Dr. James L. Kirkland

Описание: In this episode, renowned aging researcher Dr. James L. Kirkland discusses cutting-edge research on cellular senescence and senolytics in aging. He explains how senescent cells accumulate over time, accelerating aging and contributing to age-related diseases. Dr. Kirkland highlights the potential of senolytic drugs to selectively eliminate these cells, potentially delaying or preventing age-related conditions such as osteoarthritis, Alzheimer's disease, and even the impact of coronavirus infections. The episode explores challenges with senolytic therapies and how senolytic research could extend healthspan and potentially address the societal challenges of an aging population.

Note: This lecture was recorded in February 2023.

Learn more about Dr. James L. Kirkland’s work: https://www.mayo.edu/research/faculty...

Learn more about Dr. David Dodick: https://www.atria.org/doctors/dr-davi...

Time stamps:
00:00:17: Intro
00:03:05: Dr. James Kirkland on why geroscience is focused on improving healthspan as opposed to lifespan
00:05:30: The factors that impact the rate of aging
00:09:00: Cellular senescence explained
00:18:38: Developing drugs for cellular senescence
00:24:01: The role of senescent cells in pregnancy
00:24:44: Challenges to developing senolytics
00:25:36: Experimentation with senescent cells in mice
00:30:45: The spread of senescence in obesity and its effects on the brain
00:32:43: How senescent cells interact with SARS-CoV-2
00:35:20: Efforts to translate senolytic drugs to humans
00:42:00: Gerogiagnostics: Developing biomarkers that can guide interventions for targeting aging
00:46:00: Alpha-Klotho protein as a geroprotective factor and its relation to senolytics
00:48:30: Risks and benefits of clinical trials for people with serious conditions
00:53:00: The impact of senescence on childhood cancer survivors and the promise for other conditions beyond old age
00:54:44: Trials related to space travel
00:57:02: Conclusions on persistent senescent cells in animals and progress in human trials

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About:
Atria’s Vanguard Symposia is a lecture series where some of the world’s most compelling researchers translate leading-edge science into medicine. In each episode, top experts share breakthrough science about preventive health care, dive deep into headline-grabbing topics, and take you beyond the buzzwords to explain the latest in longevity science. Our show will arm you with practical information and the tools of discernment to cut through the hype and understand what matters most.

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