Preventing Alzheimer's and Small Vessel Disease In the Aging Brain with Dr. Sandra Black

Описание: In this episode, leading neurologist and dementia expert Dr. Sandra Black explores the complex interplay between Alzheimer's disease and vascular dementia. She highlights the critical role of small vessel disease in cognitive decline and emphasizes the importance of managing vascular risk factors. Dr. Black discusses promising research and prevention strategies, including advanced imaging techniques, measuring fluid biomarkers, and lifestyle interventions such as exercise, diet, and social engagement. The episode underscores the significance of a holistic approach to preserving cognitive function in older adults, leaving listeners with an understanding of new preventive strategies and the move toward personalized medicine.

Note: This lecture was recorded in June 2023.

Learn more about Dr. Sandra Black’s work: https://sunnybrook.ca/research/team/m...

Learn more about Dr. David Dodick: https://www.atria.org/doctors/dr-davi...

Time stamps:
00:00:17: Intro
00:03:20: Dr. Sandra Black introduces the prevalence of small vessel disease among people with common dementias
00:07:01: The progression of knowledge about Alzheimer's disease and treatment
00:13:14: Links between vascular health and Alzheimer’s disease
00:15:30: The importance of the brain's vascular network
00:18:30: Understanding the roles of Amyloid beta and misfolded proteins in Alzheimer’s
00:23:28: Latest imaging techniques in Alzheimer's research and the development of a brain disease model
00:25:34: Cerebral vasculopathy and vascular cognitive disorders
00:27:34: Understanding various parts of the brain and discovering perivascular spaces
00:29:24: The multiple faces of small vessel disease
00:30:26: Key small vessel disease pathologies
00:39:50: Clinical significance of deep and periventricular white matter hyperintensities
00:42:46: Cholinergic pathways and executive dysfunction: Examining memory function, hippocampi size, and task switching
00:45:29: Understanding what white matter disease looks like in the brain
00:52:37: Vascular disease and white matter disease
00:54:23: Watershed zones in the brain and their impact
00:55:01: Recent breakthroughs in fluid biomarkers
00:56:30: New developments in Alzheimer's disease drug development
00:59:20: Concerns over side-effects of Alzheimer's disease drugs
01:00:40: Advances in the treatment of Alzheimer's
01:02:41: Modifiable risk factors for dementia
01:04:54: Moving toward precision medicine and its challenges

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About:
Atria’s Vanguard Symposia is a lecture series where some of the world’s most compelling researchers translate leading-edge science into medicine. In each episode, top experts share breakthrough science about preventive health care, dive deep into headline-grabbing topics, and take you beyond the buzzwords to explain the latest in longevity science. Our show will arm you with practical information and the tools of discernment to cut through the hype and understand what matters most.

Atria Health and Research Institute aims to accelerate a global shift from reactive sick care to proactive, preventive health care. We work at the forefront of science and technology and we believe a collaborative approach to modern medicine can extend healthy life for all.

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