VACCINE MANUFACTURING FACILITY

Описание: A VACCINE MANUFACTURING FACILITY BUILT IN UNDER 5 MONTHS
Many vaccine manufacturing facilities are being built worldwide to be fully prepared to address the next pandemic or support global vaccination efforts.

The pandemic has demonstrated the shortcomings of not having access to locally manufactured vaccines, which creates a dependence on foreign vaccines, which may be challenging to obtain for financial reasons or political advantage.

This 14,000-square-foot clean room in a biomanufacturing plant was delivered less than 5 months after breaking ground for the new vaccine manufacturing facility.

The layout consists of a media preparation room, a packaging room, two subculture rooms, a buffer preparation room, personnel airlocks (PAL), and material airlocks (MAL). The vaccine factory’s clean rooms comply with good manufacturing practices (cGMP).

Project Summary:

Location: Canada
Industry: Vaccine Production / Biomanufacturing
Application: Biologics and Vaccine Manufacturing
Size: 14 000 Sq. Ft.
Cleanroom Class: GMP Grades (Grade B, C & D)

MODULAR VS. TRADITIONAL CLEANROOMS: A FASTER SOLUTION
Modular construction often occurs in sync with site and foundation work, allowing projects to be completed 30 to 50 percent faster than traditional construction. . In other words, the wall and ceiling modular panels are manufactured off-site simultaneously as the conventional (stick-built) construction breaks ground, saving a lot of time in the process.

Thanks to collaborative work between Mecart and general contractors, it has been possible to deliver high-end GMP cleanrooms in record time for the brand-new vaccine manufacturing facility.

As vaccination needs in Canada intensified during the pandemic, the demand for vaccine manufacturing facilities rose rapidly too. It became an urgent matter to provide vaccines to Canadians.

Our client came to us with a daunting challenge: to provide 14,000 square feet of clean room space for their vaccine manufacturing facility within a few months

Modular construction is known to be faster than traditional construction, but still, building and delivering 14,000 square feet of custom cleanroom in less than 5 months still represents a significant challenge.

Here are a few examples of the advantages of choosing a modular cleanroom manufacturer for your vaccine plant cleanrooms:

Modular walls can be removed to accommodate new, larger equipment as needed (2000L bioreactors, for example)
Design flexibility (mobility, expandability, etc.)
Cleaner installation on-site
Faster installation on-site (can be fully prefab off-site or assembled directly on-site)
Higher and consistent quality, since production is done under ISO 9001 quality management system at Mecart’s plant
Vaccine Manufacturing Facility Vaccine Production (2)Vaccine Manufacturing Facility Vaccine Production (1)
Vaccine Manufacturing Facility (1)
2 LEVELS OF CEILING HEIGHT TO ACCOMMODATE BIOREACTORS
Bioreactors are essential for developing and manufacturing vaccines, from small laboratory fermenters (1L to 50L capacity) to 2000-liter plant scale bioreactors.

This vaccine manufacturing facility contains different sized bioreactors for scaling up vaccine production for future pandemics. The various dimensions of their bioreactors came with the need for different ceiling heights for the 2000L bioreactors.

Air treatment and air changes are very energy consuming to maintain the cleanliness levels necessary for vaccine production. To save the customer energy and lower operation costs, Mecart came up with a solution.

Rather than having the entire clean room with 14-foot-high ceilings, 2 ceiling height levels were incorporated into the room to decrease the total amount of air to be cleaned. As seen in the picture, one of the clean rooms has a ceiling with 2 different heights to allow the 2000L bioreactors to fit without obstruction while reducing the energy bill. Here, we can see a 14-foot-high ceiling next to a 9’6’’ ceiling.

There are 4 different cleanroom ceiling heights (14 ft., 12 ft., 10 ft., and 9’6’’ ft.) in this vaccine manufacturing facility for numerous different equipment sizes, operational reasons, and cost savings.

GMP DESIGN FEATURES
Vaccine manufacturing facilities and vaccine production need to comply with GMP guidelines to assure drug safety for the end-user. In the picture above, we can see multiple flush design features used for this vaccine manufacturing facility.

Fire Sprinklers: recessed in the ceiling and come out only in case of fire
Air Returns
HEPA Filters
Flush Windows
Flush Lighting
Cleanroom Coving: Coving is a piece of material that is used to cover the seam between two surfaces, such as the intersection of two walls or the connection between a wall and the ceiling or floor
These flush finish features make it easier to clean the vaccine manufacturing facility and its cleanroom environments, making it easier to remain GMP compliant.