Solving the Key Challenges of NKG Mice | Cyagen Talk

Описание: Struggling with GvHD or poor myeloid reconstitution in your humanized mouse studies? While NKG mice are powerful, their limitations can create significant hurdles for long-term and advanced immuno-oncology research.

In this Cyagen Talk, our scientific experts discuss a more flexible and powerful approach to building a truly functional human immune system in a mouse model.

(00:13) – The Core Challenges
• Understand the two major drawbacks of standard humanized NKG models: the short experimental window caused by GvHD in PBMC models, and the lack of myeloid lineage cells (like DCs) in HSC models.

(03:29) – The Cyagen Solution: An AAV-based Approach
• Discover how we use an AAV delivery system to provide necessary human cytokines, avoiding the complexities and health issues of multi-transgenic models like MISTRG.

(04:47) – The Breakthrough: Reconstituting Functional Dendritic Cells
• See how this innovative method successfully reconstitutes functional dendritic cells (DCs)—a critical component missing in previous models—and its implications for developing tools like cancer vaccines.

💬 For IO researchers, what's a bigger challenge in your work: the short experimental window from GvHD, or incomplete immune reconstitution?
⭐️ Try NKG mice for free: https://www.cyagen.com/campaigns/nkg-...

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🔬 DISCOVER CYAGEN'S IMMUNO-ONCOLOGY PLATFORM
Explore our advanced humanized models, including the ProF™ platform, designed to accelerate your research.
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This is a valuable conversation for researchers in immuno-oncology, cell therapy, and vaccine development looking for more robust and reliable humanized models.

#ImmunoOncology #HumanizedMice #NKGmouse #GvHD #AAV #CancerVaccine #Cyagen #Immunotherapy