Phosphodiesterase 5 inhibitors Use in Erectile dysfunction Pharmacology

Описание: Phosphodiesterase inhibitors are a class of medications that promote blood vessel dilation (vasodilation) and smooth muscle relaxation in certain parts of the body, such as the heart, lungs, and genitals. Phosphodiesterases are a diverse family of enzymes that play a key role in regulating cell functions by indirectly increasing the intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), both of which are “second messengers” that regulate the primary effects of hormones and neurotransmitters.
Phosphodiesterase inhibitors work by inhibiting the phosphodiesterase enzymes, thus preventing them from breaking down cAMP and cGMP molecules in the cell. The production of cAMP and cGMP are regulated by a molecule called nitric oxide, and their function is to help regulate physiological processes by decreasing the levels of calcium in the cell. Ultimately, cAMP and cGMP are broken down by phosphodiesterase enzymes.

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