2. Drugs Used in Erectile Dysfunction (Part-1): Pharmacology

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2. Drugs Used in Erectile Dysfunction (Part-1): Pharmacology
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Erectile Dysfunction (ED) is a common condition affecting men worldwide 🌎, characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual activity 🍆❌. The treatment primarily focuses on enhancing penile blood flow 🩸, improving smooth muscle relaxation, and addressing underlying hormonal or psychological causes 🧠.

🔹 Phosphodiesterase-5 (PDE-5) Inhibitors (Sildenafil 💙, Tadalafil, Vardenafil, Avanafil) – These are the first-line therapy, acting by blocking PDE-5, an enzyme that degrades cGMP, thereby enhancing nitric oxide (NO) 🧪 effects. This leads to vasodilation 🩸, increased blood flow, and prolonged erection. Tadalafil (Cialis) lasts the longest (36 hours ⏳), while Sildenafil (Viagra) and Vardenafil last 4–6 hours. Avoid concurrent use with nitrates (e.g., nitroglycerin 🚫) due to the risk of severe hypotension.

🔹 Prostaglandin E1 (PGE1) Analog – Alprostadil 🩸 – Used in patients unresponsive to PDE-5 inhibitors, administered via intracavernosal injection 💉 or intraurethral suppository. It directly relaxes smooth muscles, improving blood flow to the corpus cavernosum.

🔹 Testosterone Replacement Therapy (TRT) 🧬 – Beneficial for men with hypogonadism (low testosterone levels), helping restore libido 🔥 and improving erection quality. Available in gels, patches, or injections 💉.

🔹 Dopamine Agonists (e.g., Apomorphine 🎭) – Used for neurogenic ED, stimulating dopamine receptors to enhance arousal and erection.

These drugs improve erectile function, boost confidence, and enhance quality of life 🌟, making them essential for ED management.

#ErectileDysfunction #PDE5Inhibitors 💊 #Sildenafil 💙 #Tadalafil #SexualHealth 🍆 #TestosteroneTherapy 🧬 #Vasodilation 🩸 #MedicalEducation 📚 #MBBSNotes #StudySmart 🧠 #MenHealth 🏋️ #NitricOxideEffect 🚀 #SafeSexualTherapy #BoostLibido 💪