PAXLOVID for COVID-19 (Part 3 - Medicine Interactions) 'Some Need-to-Know Info!' PHARMACIST Fi

Описание: PHARMACIST Fi looks at the fascinating range of ways medicine interactions with Paxlovid happen, and active ingredients of interacting medicines which are currently listed in the latest Australian Paxlovid product information (PI), U.S.A. prescribing information (USPI), and U.K. summary of product characteristics (SmPC) on 13 February 2023
(health professionals may wish to use the free University of Liverpool COVID-19 Drug Interactions Checker, or other similarly high quality medicine interactions guidance, to find a wider range of active ingredients which interact with Paxlovid than this video contains, as well as checking the latest local Paxlovid medicine information for health professionals in your country; please note that this video is only for education and is not medical advice).

PHARMACIST Fi's main reasons for making this video are to let viewers know that:

*Paxlovid interacts in different ways with different medicines

*interaction management may be very different for different medicines or different people,
for example:
whether Paxlovid can be taken or not,
whether medicine changes are needed or not,
type of medicine changes (if required),
extent of medicine changes (if required),
start and stop dates of medicine changes (if required) relative to start and stop dates of Paxlovid treatment,
whether increased monitoring for side effects or medical condition symptoms is needed,
type/s, frequency and location of increased monitoring (if required)
Paxlovid medicine interaction management partly depends on what medical conditions a person has and their kidney and liver function (these things may influence whether medicine changes can be made safely or not, or whether Paxlovid may need to be avoided for some people)

*ways to manage Paxlovid medicine interactions may change in the coming months or years due to new research (for example: the Australian Paxlovid product information for health professionals has been updated with changes twice in the past 2 months) - so it is VERY important that the doctor (or pharmacist or nurse in some countries) who is considering whether or not to prescribe Paxlovid checks the most recent medicine interaction management advice for each medicine or herb their patient is currently taking and has taken in recent weeks

*Not every medicine interacts with Paxlovid, and although some medicines interact with Paxlovid in ways that are dangerous enough that Paxlovid must not be taken by some people, some moderate medicine interactions with Paxlovid can be managed by medicine changes in some people (depending on what medical conditions they have, and their kidney and liver function), and some other medicine interactions with Paxlovid are mild enough not to need medicine changes... so a lot of people are able to take Paxlovid to help reduce risk of hospitalization or death from COVID-19 infection.

Here is the link to PHARMACIST Fi's main video about Paxlovid (called 'Part 1'):
   • PAXLOVID for COVID-19 (Part 1 - Main Video...  

Here is the link to PHARMACIST Fi's video about why it is a good idea to make a Medicines, Allergies & Contacts List with everything you take on it (and how giving copies of your Medicines, Allergies & Contacts List to your healthcare team (for example: your doctor, specialists, pharmacists, dentist, & nurse) could help reduce risk of medicine interactions and other medicine problems):
   • #1: Make a 'Medicines, Allergies and Conta...  

Here is the link to PHARMACIST Fi's video about the fascinating way Paxlovid works:
   • Paxlovid for COVID-19: 'How Does that Work...  

Here is the link to PHARMACIST Fi's video about how to take Paxlovid (because it needs to be taken a particular way to work well):
   • Paxlovid for COVID-19 (Part 2 - How to Tak...  

For those of you interested in exploring more of the science behind the info in this video about metabolizing enzymes and transporters which are involved in interactions between various medicines and Paxlovid, here are the main references for this video - so check if they may have been updated since 13 February 2023 when this video was recorded, and access the most recent versions of them:
*Australian Medicines Handbook 2023 (AMH; computer program). Adelaide: Australian Medicines Handbook Pty Ltd; 2023 January. Accessed 13 February 2023 re: Drugs & CYP Enzymes, Drugs & P-glycoprotein, Drug Interactions - Ritonavir.
*Paxlovid (nirmatrelvir with ritonavir) Summary of Product Characteristics (SmPC) Revised October 2022 (accessed from emc website)
*Paxlovid (nirmatrelvir with ritonavir) Product Information (PI) Revised 01 February 2023 (accessed from TGA website)
*Paxlovid (nirmatrelvir with ritonavir) Prescribing Information (USPI) Revised February 2023 (accessed from FDA website)
*University of Liverpool COVID-19 Drug Interactions Checker
(https://www.covid19-druginteractions.... )
*Norvir (ritonavir) Product Information (PI) Revised 2020 (accessed from TGA website)

We hope this video has been helpful for you.

Please also see disclaimer at the end of this video.