How Pfizer's New Drug Fights COVID (PAXLOVID)
Автор: Simplifying Synthesis
Загружено: 2021-04-11
Просмотров: 15498
Описание:
A guide to the mechanism of action and synthesis of Pfizer's new drugs for COVID-19.
UPDATE: PF-07321332 is now known as Nirmatrelvir and is part of the Paxlovid combination therapy.
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References:
J. Med. Chem. 2020, 63, 21, 12725–12747 (PF-00835231 report)
https://www.pfizer.com/news/press-rel... (PF-07321332 press release)
Tetrahedron 2021, 77, 131761 (3CLpro Studies)
FEBS Letters 2004, 574 131–137 (3CLpro Studies)
J. Am. Chem. Soc. 1986, 108, 1350-1351 (Inhibition by peptide nitriles)
Enzyme and Microbial Technology 1991, 13(5), 408–411 (Inhibition by peptide nitriles)
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