Enabling Binder and Molecular Glue Discovery with High-Throughput Spectral Shift Technology

Описание: Speakers:
• Vanessa Porkolab, PhD - Biophysics Director, Eurofins Discovery
• Maud Sigoillot, PhD - Biophysics Study Director, Eurofins Discovery
Discover how High-throughput Spectral Shift (HT-SpS) technology accelerates binder and molecular glue discovery for some of the most challenging targets, including proteins with allosteric sites and complex protein–protein interactions.
This is enabled by a high-throughput, affinity-based workflow powered by the Dianthus uHTS (NanoTemper®) and seamlessly integrated with Genedata Screener® for automated data processing and analysis.
Key Areas Covered:
• How HT-SpS scales early hit-finding to 65,000+ data points per day with minimal protein input and no immobilization.
• Why HT-SpS is uniquely powerful: a site-agnostic, affinity-based alternative that complements or outperforms AS-MS and DEL for challenging targets.
• PIM3 kinase case study demonstrates how HT-SpS identifies new chemical spaces not previously accessible through conventional HTS approaches.
• Using CRBN as the E3 ligase, HT-SpS detects and characterizes binary and ternary complexes, showcasing its ability to identify molecular glues.

For more about our Biophysics expertise, click here: https://emea.eurofinsdiscovery.com/so...
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“Key Moment/Chapters”:
• Introduction: 0:00 – 5:08
• Presentation HT-SpS: 5:08 – 10:37
• Case Studies: 10:38 – 34:12