Prodrug| Types| Classification| Application| Pharmacology| Medicinal Chemistry| Made Easy

Описание: A prodrug is a chemically modified inert drug precursor which upon biotransformation liberates the pharmacologically active parent compound. This video will explain about what is a prodrug, various types of prodrugs, classification of prodrug and application of prodrug in medicinal chemistry and pharmacology.
Depending on the constitution, lipophilicity, and method of bio-activation, pro-drugs are classified into two categories.
▪ Carrier-linked pro-drugs
▪ Bio-precursors
The ideal properties of pro-drugs are as follows:
▪ Drug and the carrier linkage must be cleared in vivo.
▪ It should not have intrinsic pharmacologic activity.
▪ It should rapidly transform, chemically or enzymatically, into the active form where desired
▪ The metabolic fragments, apart from the active drug, should be nontoxic.
The aim of pro-drug development is, in most cases, to solve specific pharmaceutic or pharmacological and pharmacokinetic problems.
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Chapters:
0:00 - Intro
0:22 - Approaches to from prodrug
0:55 - Prodrug (Definition)
1:16 - Properties of Prodrug
1:41 - Classification of Prodrug
1:58 - Carrier Linked Prodrug
2:24 - Bio precursor Prodrug
2:47 - Types of Prodrug
3:02 - Applications of Prodrug
3:14 - Pharmaceutical Applications of Prodrug
3:46 - Pharmacokinetic Applications of Prodrug

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"Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition."
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