Studying GPCR Pharmacology in Patient-Derived iPSC Models | Terry Ebert / Masterclass 22I

Описание: Most GPCR pharmacology is still mapped in heterologous cell lines.

But how well do those signaling profiles translate to real human tissues?

In this discussion, Dr. Terry Ebert explores how patient-derived induced pluripotent stem cell (iPSC) systems are changing the way researchers study GPCR signaling and pharmacology. These models allow investigators to examine receptor function in cellular contexts that more closely reflect native human biology.

The conversation examines how iPSC-derived cells are generated and adapted for pharmacological assays, including strategies for monitoring receptor activity using live-cell biosensors. As GPCR signaling is increasingly studied in tissue-engineered systems and organoid models, researchers gain new opportunities to analyze receptor signaling within physiologically relevant environments.

These advances raise important questions for drug discovery. How do signaling dynamics change when receptors are studied in human cell types rather than simplified expression systems? And how can biosensor technologies be adapted to track signaling pathways in these complex models?

This discussion comes from the Dr. GPCR Masterclass, a live scientific forum where GPCR researchers engage directly with leading experts to explore current discovery challenges and emerging ideas shaping the field.

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TIMESTAMPS

00:00 — The challenge of translating GPCR signaling from cell lines
00:38 — Why cellular context matters for receptor pharmacology
01:15 — Generating iPSC-derived cell models
02:05 — Biosensors for monitoring GPCR signaling in living cells
03:10 — Organoids and tissue-engineered systems in pharmacology
04:05 — Implications for translational GPCR drug discovery

HASHTAGS

#GPCR
#DrugDiscovery
#Pharmacology
#BiotechResearch
#GPCRScience
#StructuralBiology
#MedicinalChemistry
#TranslationalScience

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