Dose dependent study of best LNPs (TEA-LNPs) formulations
Автор: Informative
Загружено: 2026-01-15
Просмотров: 3
Описание:
Gist: After finalizing three candidates for further analysis i.e., TEA 13, TEA 37 and TEA 41. Researchers used primary human T-cells from donors for dose dependent studies for three different time periods i.e., 24 h, 48h, and 72h. All the three conditions show does dependent increase in the fluorescence as they use Cy5-eGFP mRNA in this study, however signals from the TEA 41 are relatively lower compared to TEA 13 and TEA 37. Thereafter cell viability is also monitored is found to be comparable to the positive control in which PBS is used. For negative control DMSO is also, where lower viability is evident.
#cartherapy #tcells #transfection #lipidnanoparticles #lnp #biology #cancertreatment #cartadvancement #mRNA #cd4tcell #tealnp #cartcells #immuneresponse #immunesystem #designofexperiment #doe #taelnps #dosedependent #cellviability
Reference:
https://doi.org/10.1021/acsnano.5c15903
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