Corticobasal Degeneration: Asymmetric Brain Death

Описание: Corticobasal degeneration is a rare neurodegenerative disease characterized by progressive, asymmetric damage to the cerebral cortex and basal ganglia. Unlike many neurological disorders, degeneration does not occur evenly across the brain. One side deteriorates faster, creating profound imbalance between intention, perception, and motor control.

This medical documentary examines how corticobasal degeneration disrupts movement planning, sensory integration, and voluntary control. As neurons degenerate unevenly, one limb may become rigid, unresponsive, or act independently of conscious intention, while awareness remains intact. Speech, coordination, and executive function deteriorate as affected brain networks lose the ability to communicate reliably.

The condition is frequently misdiagnosed in its early stages, but the underlying pathology progresses regardless. There is no reversal and no stabilization. Decline is defined by increasing loss of agency on one side of the body while cognition and awareness may persist.

This is Pathology of Fear.
And this fear is real.
Because sometimes the most devastating outcome is not global brain failure,
but watching one half of the brain die while the other remains aware of what is being lost.

Chapters
00:00 Corticobasal Degeneration – Clinical Introduction
01:08 Tau Protein Pathology and Neurodegeneration
02:31 Early Asymmetric Motor Dysfunction Explained
03:50 Supplementary Motor Area Failure
04:35 Basal Ganglia Degeneration vs Parkinson’s Disease
05:56 Ideomotor Apraxia and Cortical Motor Planning Failure
06:44 Parietal Cortex Degeneration and Sensory Integration Loss
07:44 Misdiagnosis in Corticobasal Degeneration
08:28 Executive Dysfunction and Frontal Lobe Involvement
09:39 Point of No Return in Corticobasal Degeneration
11:16 Progressive Limb Apraxia and Spatial Neglect
12:49 Dystonia, Rigidity, and Loss of Motor Inhibition
14:25 Speech Apraxia and Cortical Swallowing Failure
16:23 Neuroimaging Findings: MRI and FDG-PET
17:55 Bilateral Cortical Spread and Functional Collapse
19:29 Loss of Voluntary Control and Upper Motor Neuron Failure
21:21 Falls, Gaze Control, and Postural Reflex Breakdown
23:02 Akinetic State from Cortical Initiation Failure
25:43 Reflexive Movement Without Voluntary Control
27:21 Utilization Behavior and Frontal Release Phenomena
30:26 Advanced Corticobasal Degeneration – Loss of Agency
34:35 Final Stable Phase of Corticobasal Degeneration