Primary Progressive Aphasia (PPA): Language Network Failure

Описание: Primary Progressive Aphasia (PPA) is a progressive neurodegenerative disorder characterized by the selective breakdown of the brain’s language networks. This episode examines the biological mechanisms behind PPA, focusing on degeneration within the left frontal and temporal lobes and the white-matter pathways responsible for speech production and comprehension.

Unlike stroke-related aphasia, Primary Progressive Aphasia develops gradually as neurons within language-dominant regions are destroyed over time. As these networks deteriorate, patients experience worsening difficulty with speech, word retrieval, comprehension, reading, and writing, while other cognitive functions may initially remain intact.

This documentary traces PPA from its earliest clinical signs through silent progression and irreversible language loss. Symptoms are presented in strict causal order: regional cortical degeneration leads to network disconnection, followed by impaired communication and eventual global neurological involvement. The approach remains clinical and mechanistic, without metaphor or dramatization.

Pathology of Fear documents real neurological diseases through a medical-documentary lens. This episode is intended for viewers interested in neurology, cognitive disorders, neurodegenerative disease, and the biological mechanisms behind language loss.

VIDEO CHAPTERS

00:15 Primary Progressive Aphasia – Clinical Entry Without Memory Loss
02:30 Neuroimaging Evidence of Focal Language Network Degeneration
03:24 What Primary Progressive Aphasia Is and Is Not
04:45 Language as a Distributed Neural Network
05:22 Early Speech, Comprehension, and Repetition Failure
06:48 Why Primary Progressive Aphasia Is Commonly Misdiagnosed
07:27 Progressive Network Degeneration Without Recovery
08:40 Spread Beyond Focal Language Regions
09:54 Inferior Frontal and Temporal Lobe Language Failure
11:37 White Matter Tract Degeneration in Language Networks
12:28 Failure of Compensation and Network Collapse
13:15 Language Loss Reshaping Cognition and Social Function
15:15 Why Therapy Cannot Halt Neurodegeneration
17:07 Molecular Drivers: Tau, TDP-43, and Alzheimer Pathology
20:36 Clinical Variants of Primary Progressive Aphasia Explained
24:26 Non-Fluent, Semantic, and Logopenic Variants
29:42 Convergence Toward Global Language Failure
31:57 Diagnostic Delay and Therapeutic Limits
36:15 Collapse of Symbolic Communication Systems
37:26 Point of No Return in Primary Progressive Aphasia
39:18 Loss of Language With Preserved Consciousness
41:29 Stable Neurological Aftermath
47:31 Final State of Primary Progressive Aphasia Explained