Germline gene editing...might we be accidentally modifying the human lineage?
Автор: Kevin Curran
Загружено: 2024-06-15
Просмотров: 99
Описание:
Designing a gene editing clinical trial requires a thoughtful approach towards the accidental editing of sperm and egg cells.
The consensus opinion among governing bodies… is that we are comfortable delivering edits to adult cells, but we are not ready to deliver gene edits into germ cells. Germline cells include sperm, eggs or embryos. DNA edits delivered into germline cells may be passed on to children and, in doing so, may alter the downstream human lineage.
In contrast, DNA edits delivered to adult cells, like bone marrow stem cells, is called somatic cell editing. Somatic cell edits will only alter the treated individual and are much less controversial than germline editing.
Here’s the issue…we may see accidental germline editing as we intend to deliver gene editing medicine into adult cells in the human body. This is not an issue at all with ex vivo gene editing (Casgevy) but it is a concern with in vivo gene editing.
So far, there is no clinical trial evidence that this is happening.
But, there is evidence that accidental germline edits are a possibility.
Повторяем попытку...
Доступные форматы для скачивания:
Скачать видео
-
Информация по загрузке:
