Mitophagy in Repair of Osteonecrosis

Описание: This week at Journal Club, Kayla presents Zhang et. al. 2020 "P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head" published in Cell Death and Disease on 20 January 2023. The work explored how oxidative stress induces early osteonecrosis of the femoral head through stress-related cell aging and apoptosis, which can be alleviated by BMSC transplantation enhanced by manipulating Parkin and P53 to improve mitophagy.

Link to full article:
https://www.nature.com/articles/s4141...

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Chapters:

00:00-02:01 Introduction and Background
02:02-02:56 Study Design
02:57-05:49 Results - Osteogenesis of BMSCs in vivo
05:50-06:39 Results - OS Led to Accumulation of Damaged Mitochondria
06:40-08:05 Results - Stress Induced Apoptosis and Senescence
08:06-10:04 Results - Enhancing Mitophagy Against Stress-Induced Apoptosis and Senescence in BMSCs
10:05-11:30 Results - Effects of Mitophagy Co-regulated by P53 and Parkin on Stress-Induced Apoptosis and Aging
11:31-12:51 Results - P53 Regulated Mitophagy via the PINK1-Parkin Pathway
12:52-15:57 Results - P53 and Parkin Co-Regulated Mitophagy in BMSCs
15:58-16:36 Summary and Conclusion