Is aging linear or non-linear?

Описание: Now, as a biochemist, it won’t come as a surprise when i say i like proteins. In fact, i have dressed up as proteins more than occasion.. Proteins are the molecular machines, the enzymes, the structural components, the dynamic elements of the cell. They do stuff. And that’s a good thing, not just for our cells, but also for us understanding aging. If protein X goes up or down with age, this could provide us with actionable information. Now, this idea is not novel - in fact, one of the earliest videos i made on this channel was about undulating changes in the human plasma proteome with age. While that is still a great paper, and we’ll come back to it later, a new paper has come out with and used a much larger dataset, to create a proteomic aging clock to predict mortality and risk of common-age related diseases. Let’s take a look at what this is all about and what we can learn from these findings. And then compare there results with another new paper that looked at multiple biological variables to observe non-linear changes?

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References:
Shen, X., Wang, C., Zhou, X. et al. Nonlinear dynamics of multi-omics profiles during human aging. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00...
Argentieri, M.A., Xiao, S., Bennett, D. et al. Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med (2024). https://doi.org/10.1038/s41591-024-03...

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

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