Biomarker correlates of clinical outcomes from the Phase Ib study of JNJ-4496 in patients with DLBCL
Автор: VJHemOnc – Video Journal of Hematology & HemOnc
Загружено: 2026-02-25
Просмотров: 21
Описание:
Krish Patel, MD, Sarah Cannon Research Institute, Nashville, TN, provides insight into the biomarker correlates of clinical outcomes from the Phase Ib study (NCT05421663) of JNJ-90014496 (JNJ-4496; prizloncabtagene autoleucel) in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Dr Patel notes that this dual-targeting approach may help overcome antigen escape, a potential limitation of single-antigen-targeting CAR T-cells, and that future head-to-head clinical trials will help define the role of dual-antigen-targeting CAR-T constructs in the DLBCL treatment landscape. This interview took place virtually.
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