Investigating the integration of low-dose TBI into lymphodepletion to enhance CAR-T efficacy in LBCL
Автор: VJHemOnc – Video Journal of Hematology & HemOnc
Загружено: 2026-03-02
Просмотров: 16
Описание:
In this video, Mohammad Alhomoud, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the potential impact of integrating low-dose total body irradiation (TBI) into lymphodepletion for CD19 CAR T-cell therapy in large B-cell lymphoma (LBCL). In preclinical murine models, low-dose TBI enhanced CAR-T efficacy through several mechanisms, resulting in superior disease control and improved survival. This interview took place virtually.
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