Biochemistry Chapter 11 | Porphyrias: Heme Synthesis Regulation, AIP and PCT For Step 1

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In this Biochemistry Chapter 11 lesson, we walk through porphyrias by mapping the heme synthesis pathway step by step, then tying each enzyme to the classic USMLE Step 1 clues you are expected to recognize. You will also learn the rate limiting step, the lead inhibited enzymes, and how pathway regulation explains common triggers and treatments.

Covered in this video:
• Heme synthesis and key intermediates
• ALA synthase regulation and common triggers
• Lead inhibited enzymes
• Sideroblastic anemia buzzwords
• AIP presentation, triggers, diagnosis, treatment
• PCT rash, Woods lamp urine, risk factors
• High yield differential
• Step style question walk through with carbamazepine

⏱️ Timestamps
00:43 Heme synthesis overview and porphyrias roadmap
01:06 High yield porphyrias: AIP and PCT
03:34 ALA synthase, rate limiting step, B6
04:18 ALA dehydratase and lead inhibition
05:25 Uroporphyrinogen III synthesis and pathway flow
08:26 Ferrochelatase adds iron and lead inhibition
09:26 Sideroblastic anemia preview
10:27 AIP overview: PBG deaminase deficiency
11:27 PCT overview: UROD deficiency and skin findings
12:54 Heme synthesis regulation and sideroblastic anemia
24:24 Acute intermittent porphyria deep dive
36:02 Porphyria cutanea tarda deep dive
44:18 Step style question walk through

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