Acetaminophen Toxicity Explained | Stages, Diagnosis & N-Acetylcysteine Treatment | CanadaQBank

Описание: In this high-yield emergency medicine and toxicology review, we break down Acetaminophen (Paracetamol) Toxicity — the most common cause of acute liver failure in many countries.
This video covers the stages of toxicity, clinical presentation, key diagnostic tools, and management protocols, making it ideal for USMLE Step 1, Step 2 CK, NCLEX, PLAB, PANCE, and medical/nursing school exams.


What You Will Learn

Mechanism of toxicity (NAPQI buildup, glutathione depletion)
Stages of acetaminophen poisoning (0–4)
Early vs late symptoms
When to use the Rumack–Matthew Nomogram
Indications for N-Acetylcysteine (NAC) therapy
High-yield exam scenarios and lab findings
Management in delayed presentation and chronic overdose

Key Topics Covered

Toxic dose thresholds (mg/kg)
Elevated AST/ALT, high INR, metabolic acidosis
NAC: mechanism, dosing routes (oral vs IV)
Fulminant hepatic failure signs
When to consider liver transplant referral
Co-ingestions + risk factors (alcohol, malnutrition)

Perfect For

Medical students & nursing students
USMLE Step 1 & Step 2 CK prep
NCLEX & PANCE learners
Emergency medicine review
Anyone studying high-yield toxicology topics

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#AcetaminophenToxicity #ParacetamolOverdose #Toxicology #EmergencyMedicine #USMLE #NCLEX
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