Clonal evolution and genetic drivers of progression in CLL
Автор: VJHemOnc – Video Journal of Hematology & HemOnc
Загружено: 2026-03-12
Просмотров: 7
Описание:
Romain Guièze, MD, PhD, CHU Clermont Ferrand, Clermont Ferrand, France, discusses clonal evolution in chronic lymphocytic leukemia (CLL), highlighting how genetic diversification and selective pressures drive subclonal dynamics and disease progression. He also outlines recent insights into the genomic drivers of Richter's transformation and mechanisms of resistance to venetoclax, including MCL1 amplification. This interview took place at the ESH CLL 2026 congress in Stockholm, Sweden.
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