Alkylation of Stabilized Enolates | Malonate & β-Keto Ester Synthesis Explained
Автор: Sami Varjosaari
Загружено: 2021-02-13
Просмотров: 164
Описание:
In this video, we explore how stabilized enolates—particularly from β-keto esters and dialkyl malonates—are used to form new carbon–carbon bonds through alkylation reactions. These compounds act as powerful nucleophiles and versatile synthons, allowing for strategic carbon skeleton building in organic synthesis.
Topics Covered:
Why β-keto esters and malonates are easily deprotonated at the α-position
Formation of stabilized enolates and their use in C–C bond formation
Role of these molecules as synthons in multi-step synthesis
Two key follow-up steps:
Hydrolysis of esters to carboxylic acids
Decarboxylation under acidic heat to yield the final product (ketone or substituted acid)
Examples with full stepwise transformations
Practice problems with solutions to reinforce key concepts
💡 Perfect for understanding how to build complex molecules using enolate chemistry, with focus on clean synthetic strategy via removable ester groups.
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