26: Glycation and Skin Aging with Dr. Paul Reynolds

Описание: In this essential episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—uncovers how glycation silently accelerates skin aging. Building on previous episodes exploring glycation’s impact on organs and metabolism, Dr. Reynolds now turns to the body’s largest and most visible organ: the skin.

Glycation, the process by which sugar molecules bind to proteins and fats, forms toxic compounds known as AGEs (advanced glycation end products). These AGEs attack collagen and elastin—the proteins that keep skin firm, supple, and resilient. By crosslinking these fibers and activating inflammatory pathways like RAGE, glycation stiffens the skin, reduces elasticity, and triggers oxidative stress. The result? Wrinkles, sagging, and premature aging from the inside out.

This lecture connects the dots between molecular biochemistry, lifestyle, and visible aging. From sugar-laden diets and high-heat cooking to UV exposure and smoking, Dr. Reynolds explains how daily habits accelerate AGE buildup—and how strategic interventions can reverse the damage. Backed by peer-reviewed research, this episode translates complex cellular science into practical, evidence-based tools for lifelong skin health and resilience.

Topics Covered
-What glycation is and how it affects collagen and elastin
-How AGEs crosslink skin proteins and trigger inflammation
-The RAGE receptor and oxidative stress in aging skin
-Diet, cooking methods, and lifestyle factors that accelerate glycation
-The impact of UV light and smoking on AGE formation
-Diabetic skin complications and impaired wound healing
-AGE inhibitors and antioxidants that protect the skin
-Practical nutrition and skincare strategies for youthful skin

Timestamps:
00:00 – Introduction: Glycation and Skin Aging
00:36 – Why You Should Care About Glycation
01:10 – What Glycation Really Is
01:49 – How Glycation Damages Collagen and Elastin
02:29 – Why Skin Is So Vulnerable
03:09 – How Glycation Stiffens Collagen (2013 Study)
03:50 – Inflammation and RAGE Receptor Activation
04:32 – External Factors That Worsen Glycation
05:16 – Diet: Sugars, Cooking Methods & AGE-Rich Foods
05:56 – Better Diets: Mediterranean & Low-AGE Eating
06:38 – Sunlight, UV Exposure & Oxidative Stress
07:21 – Smoking and Accelerated Skin Aging
08:07 – Lifestyle Habits That Trigger Glycation
08:47 – Diabetes and Skin Complications
09:33 – How Glycation Impairs Wound Healing (2017 Study)
10:15 – Even Non-Diabetics Are Affected
10:52 – What You Can Do: Practical Strategies
11:31 – Low-AGE Diets and Nutritional Studies
12:12 – Daily UV Protection & Sunscreen Research
12:53 – Antioxidants for Skin Defense
13:34 – AGE Inhibitors and Emerging Science
14:20 – AGE Breakers and Experimental Compounds
15:01 – Glycation Beyond Skin: Systemic Effects
15:42 – Your Skin as a Metabolic Health Indicator
16:20 – Final Takeaways & Lifestyle Advice
16:58 – Closing Thoughts

Whether you’re passionate about skincare, interested in healthy aging, or exploring the molecular roots of beauty, this episode reveals how metabolic health literally shows on your face—and how controlling glycation can help preserve elasticity, glow, and long-term skin vitality.

About Dr. Paul Reynolds
Dr. Reynolds is a biomedical scientist and professor at Brigham Young University, known for translating complex cellular biochemistry into clear, actionable insights. His College of Glycation series empowers students and lifelong learners to understand and combat the molecular processes that drive aging, chronic disease, and now—skin health.

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