The role of IL-15 in leukemia - Video abstract [ID 78347]
Автор: Dove Medical Press
Загружено: 2015-04-09
Просмотров: 664
Описание:
Video abstract of a review paper "IL-15 as a potential target in leukemia" published in the open access Blood and Lymphatic Canceter Targets & Therapy journal by Xiong Y, Bensoussan D, Decot V.
Abstract: Leukemia, one of the most aggressive hematopoietic malignancies, is characterized by excessive proliferation, survival, and impaired differentiation of hematopoietic stem cells. Interleukin 15, a proinflammatory cytokine, induces proliferation and promotes cell survival of human T and B lymphocytes, as well as natural killer cells. However, it may also play a detrimental role in the onset of leukemia. This review provided an overview of the aberrant expression of Interleukin 15 and its role in the development and progression of this hematological malignancy. Also, we critically explored the potential therapeutic opportunities involved in targeting the disruption of interleukin-15 signaling as well as in interleukin-15-mediated enhancement of antitumor immunity.
Read the full review paper here: http://www.dovepress.com/il-15-as-a-p...
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