Buffers & Ionisation (pH–pKa) | Weak Acids vs Weak Bases | Physical Pharmacy
Автор: Khan Virtual Academy
Загружено: 2026-02-04
Просмотров: 46
Описание:
In this video, we explain Buffers and Ionisation (pH–pKa) in an easy, exam-focused way. Learn what buffers are, how they resist changes in pH, and how to calculate buffer pH using the Henderson–Hasselbalch equation. We also cover ionisation of weak acids and weak bases, the effect of pH on drug ionisation, pH-partition hypothesis, and why ionisation matters for solubility, dissolution, permeability, absorption, and bioavailability—especially in GIT.
✅ Topics covered:
Buffer solutions (acidic/basic buffers)
Henderson–Hasselbalch equation
Buffer capacity & factors affecting it
pH, pKa, and percent ionisation
Ionisation of weak acids vs weak bases
pH–solubility & pH–permeability relationship
Clinical relevance: absorption in stomach vs intestine
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