Part 2: Polymorphism Explained | Enantiotropic vs Monotropic
Автор: Khan Virtual Academy
Загружено: 2026-02-03
Просмотров: 68
Описание:
In this video, we explain Polymorphism in a simple and exam-focused way. Polymorphism is the ability of a substance (especially drugs) to exist in more than one crystalline form, which can change important properties like solubility, dissolution rate, stability, melting point, and bioavailability. We discuss types of polymorphism (enantiotropic vs monotropic), pseudopolymorphism (hydrates/solvates), methods of identification (XRD, DSC, IR, microscopy), and why polymorphism matters in formulation, manufacturing, and quality control.
✅ Covered in this lecture:
Definition & importance of polymorphism
Crystalline vs amorphous forms
Enantiotropic vs monotropic systems
Hydrates/solvates (pseudopolymorphism)
Effects on solubility, stability, dissolution & bioavailability
Characterization methods (XRD, DSC, DTA, IR, microscopy)
#Polymorphism #PhysicalPharmacy #Pharmaceutics #CrystalForms #DrugSolubility #Dissolution #Bioavailability #XRD #DSC #Hydrates #QualityControl #PharmacyStudents
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