Single-cell DNA damage analysis reveals selective genome vulnerability

Описание: Learn how Paired-Damage-seq enables simultaneous profiling of oxidative DNA damage and the transcriptome.

In this webinar with our partner ‪@EpigenomeTechnologies‬ our guest speaker Chenxu Zhu, PhD, of the NY Genome Center, explains how Paired-Damage-seq, a groundbreaking #SingleCell #Multiomics method that employs CUT&Tag to directly target regions of #DNAdamage within the genome, reveals cell-type-specific damage patterns linked to epigenetic states and offers new insights into disease mechanisms.

In this webinar, you will learn about:

The challenges with existing approaches to studying DNA damage in single cells
The fundamentals of Paired-Damage-seq, a scalable single-cell multiomics platform that utilizes a “labeling-by-repair” strategy and combinatorial indexing to simultaneously capture oxidative/single-stranded DNA damage and the transcriptome within the same cell
How to get started with the experimental workflow of Paired-Damage-seq and its integration with additional multimodal single-cell datasets
Potential new applications in neurodegeneration, cancer, and aging research by identifying cell-type-specific “vulnerability hotspots”
This webinar will be of interest to researchers in genomics, epigenetics, single-cell biology, and disease biology who are looking to expand their toolkit for studying genome instability.

This webinar will be of interest to researchers in genomics, epigenetics, single-cell biology, and disease biology who are looking to expand their toolkit for studying genome instability.