Brain Cell Replacement to Beat Aging | Jean M. Hebert, Albert Einstein School of Medicine

Описание: Seminar summary: https://foresight.org/summary/brain-c...

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Jean M. Hebert, Ph.D. Albert Einstein School of Medicine: Bran Cell Replacement to Beat Aging

Brain cell replacement as the cornerstone to beating aging an effective means of fighting the aging process per se. In contrast, replacing the body’s cells and tissues would reverse all age-related damage at once, resetting the clock to zero. Advances in regenerative medicine have already made such replacements possible in humans for certain parts of the body and will soon make them possible for all parts. For the brain, replacement as a strategy to reverse aging requires careful consideration to avoid interruptions in function and self-identity. The brain, particularly the neocortex (the part of the brain used for our highest forms of cognition), is remarkably plastic. This plasticity, even in older humans, has allowed, for example, the slow relocation over time of functions as complex as language from one neocortical substrate to another without overt discontinuity in function. This plasticity, combined with the demonstrated ability of immature neocortical cells, once transplanted into the adult brain, to differentiate and form synaptic connections with normal short and long-distance targets, provide the basis for a brain rejuvenation strategy using progressive replacement. The goal of the Hébert team is to engineer fully functional human neocortical tissue. The strategy for achieving this goal is to combine in transplants a normal complement of immature neocortical cell types (neuronal, glial, and vascular) in a laminar cytoarchitecture that recapitulates normal neocortical tissue. Success in engineering neocortical tissue will have broad implications on how we treat brain damage in general, and in particular will provide the key to reversing progressive brain degeneration and beating aging.

About Jean Hebert:
Jean Hebert is Professor in the Dominick P. Purpura Department of Neuroscience, and Professor in the Department of Genetics. His research is focused on devising methods of cell replacement for the adult neocortex when its cells are lost due to damage or age-related degeneration.

Zoom Transcription:
https://otter.ai/u/LZN6conPV0ZdRXEyVn...

Find a written summary of this talk here (including slides, notes and more):
https://foresight.org/salon/brain-cel...

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