Reversing Epigenetic Age with Alpha-Ketoglutarate? | Brian Kennedy, Ph.D.

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This clip is from episode #357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.

In this clip, they discuss:

Chronological vs. Biological Age – Peter explores whether biological clocks can outperform chronological age in predicting lifespan and health
Development of Clinical Chemistry Clocks – New “second-generation” biological clocks are being built from standard clinical data
Superior Mortality Prediction – The second-gen clinical chemistry clocks predict mortality better than ASCVD risk scores and some epigenetic clocks
Hospitals Are Taking Interest – Hospitals prefer these models because they're based on tests they already understand and use regularly
Actionable Health Insights – Doctors can act on this data—like treating LDL or hypertension—potentially reducing biological age and mortality risk

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The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.

Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.

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