Na Cai | Phenotype integration improves power and preserves specificity in biobank-bas...| CGSI 2022

Описание: Na Cai | Phenotype integration improves power and preserves specificity in biobank-based genetic studies of Major Depressive Disorder

Related papers:

1. Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, Clarke TK, Forstner AJ, Grabe HJ, Hamilton SP, Levinson DF, Lewis CM, Lewis G, Martin NG, Milaneschi Y, Mors O, Müller-Myhsok B, Penninx BWJH, Perlis RH, Pistis G, Potash JB, Preisig M, Shi J, Smoller JW, Streit F, Tiemeier H, Uher R, Van der Auwera S, Viktorin A, Weissman MM; MDD Working Group of the Psychiatric Genomics Consortium, Kendler KS, Flint J. Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nat Genet. 2020 Apr;52(4):437-447. doi: 10.1038/s41588-020-0594-5. Epub 2020 Mar 30. PMID: 32231276; PMCID: PMC7906795.

2. Dahl, A., Iotchkova, V., Baud, A., Johansson, Å., Gyllensten, U., Soranzo, N., Mott, R., Kranis, A., & Marchini, J. (2016). A multiple-phenotype imputation method for genetic studies. Nature genetics, 48(4), 466–472. https://doi.org/10.1038/ng.3513

3. Turley, P., Walters, R. K., Maghzian, O., Okbay, A., Lee, J. J., Fontana, M. A., Nguyen-Viet, T. A., Wedow, R., Zacher, M., Furlotte, N. A., 23andMe Research Team, Social Science Genetic Association Consortium, Magnusson, P., Oskarsson, S., Johannesson, M., Visscher, P. M., Laibson, D., Cesarini, D., Neale, B. M., & Benjamin, D. J. (2018). Multi-trait analysis of genome-wide association summary statistics using MTAG. Nature genetics, 50(2), 229–237. https://doi.org/10.1038/s41588-017-00...

4. Mazumder, R., Hastie, T., & Tibshirani, R. (2010). Spectral Regularization Algorithms for Learning Large Incomplete Matrices. Journal of machine learning research : JMLR, 11, 2287–2322.

5. Mitchell, B. L., Thorp, J. G., Wu, Y., Campos, A. I., Nyholt, D. R., Gordon, S. D., Whiteman, D. C., Olsen, C. M., Hickie, I. B., Martin, N. G., Medland, S. E., Wray, N. R., & Byrne, E. M. (2021). Polygenic Risk Scores Derived From Varying Definitions of Depression and Risk of Depression. JAMA psychiatry, 78(10), 1152–1160. https://doi.org/10.1001/jamapsychiatr...