KS Insight: Gene Regulation: From Mechanisms to Disease (J3)

Описание: About Keystone Symposia Insights

Keystone Symposia Insights are panel discussions recorded on digital video that feature Keystone Symposia meeting organizers discussing the state of their respective fields. These thought leaders provide perspectives on current and future trends.


The panel is asked to discuss the following topics:

What is the state of this field? (What did we learn at the meeting?)
Where is the field heading?
What are the opportunities and challenges ahead?


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Gene Regulation: From Mechanisms to Disease (J3)

Organizer(s) Karen Adelman and Patrick Cramer
January 26—30, 2020
Keystone Resort • Keystone, CO USA


Summary of Meeting:

Organismal development, homeostasis and healthy aging all rely on precise control of gene expression programs. Recent technological advances in structural biology, real-time imaging, and next generation sequencing have shed new light on decades-old questions about gene regulation, and we seek to highlight these advances. This meeting aims to bring together pioneers in cryoEM, single-cell microscopy, single cell sequencing and three-dimensional genome architecture, with leading experts in transcriptional regulation, to seed new collaborations and discoveries. This conference provides an ideal environment to foster interactions between transcriptional biologists and experts in single cell imaging and genomic approaches and spur conversations about how to interweave new techniques for structural biology with our growing appreciation that many critical interactions involve intrinsically disordered domains (which are by definition not well behaved in most structural approaches). Participants will attend sessions that critically evaluate the impact of genome organization on gene expression. The conference will also expose trainees to the best science possible and instill in them the enthusiasm we feel for the future of the field. Finally, pairing of this meeting with Cancer Epigenetics is ideal as the topics are inherently related. This allows our meeting to focus on underlying mechanisms and normal developmental systems, while enabling the audience to attend lectures in gene dysregulation in cancer. We plan two joint sessions to maximize interactions.

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Copyright Keystone Symposia, 2020. All rights reserved.

About Keystone Symposia:
Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists.



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