A (Very) Brief History of Life Extension | LifeXtenShow

Описание: Interest in life extension might seem to be a fairly recent phenomenon, but it is almost as old as humanity itself. Let's take a look at the history of life extension and some of humanity's attempts—some promising, some hilariously wrong—to cheat aging and death.

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Images:
The Fountain of Youth : Gemäldegalerie museum, Berlin
Herodotus: Metropolitan Museum of Art, by © Marie-Lan Nguyen / Wikimedia Commons / CC-BY 2.5
Gilgamesh: Musée du Louvre Darafsh
Tithonus: Musée du Louvre, Canino Collection, 1845
Qin Shi Huang: Wikimedia commons
Metchnikoff: Wellcome Library
Leonard Hayflick: Stanford Medical History Center
Carol Greider: Keith Weller/Johns Hopkins University School of Medicine
Elizabeth Blackburn: Science History Institute
Buck Institute: ResearcherQ
Aubrey de Grey: Stifterverband

Music:

Intro jingle courtesy of Kevin MacLeod - Incompetech.com

"Onion Capers" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 License http://creativecommons.org/licenses/b...

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Sources:

Fountain of Youth in Herodotus' work: http://penelope.uchicago.edu/Thayer/E...

Defeat of aging as an ancient dream :
Zorea, Aharon (2017). Finding the Fountain of Youth: The Science and Controversy Behind Extending Life and Cheating Death.

The Epic of Gilgamesh: https://mythology.stackexchange.com/q...

Bizarre attempts at immortality:
https://en.wikipedia.org/wiki/Gunpowd...
https://en.wikipedia.org/wiki/Qin_Shi...

Hayflick limit:
Hayflick L. (1965). "The limited in vitro lifetime of human diploid cell strains". Exp. Cell Res. 37 (3): 614–636. (Also available here: https://www.sciencedirect.com/science...)

Telomerase:
Olovnikov, A. M. (1973). A theory of marginotomy. Journal of Theoretical Biology, 41(1), 181–190. doi:10.1016/0022-5193(73)90198-7

Cohen S, Graham M, Lovrecz G, Bache N, Robinson P, Reddel R (2007). "Protein composition of catalytically active human telomerase from immortal cells". Science. 315 (5820): 1850–3.
(Also here: https://science.sciencemag.org/conten...)

Buck Institute's website:
https://www.buckinstitute.org/

Books by Aubrey de Grey:

The Mitochondrial Free Radical Theory of Aging, Volume 9 of Molecular biology intelligence unit, ISSN 1431-0414

Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime, St. Martin's Press

SENS Foundation's website:
https://www.sens.org

Methuselah Foundation's website:
https://www.mfoundation.org

Methuselah Foundation's cooperation with NASA: https://www.nasa.gov/directorates/spa...

Epigenetic clocks:
https://en.wikipedia.org/wiki/Epigene...
https://www.leafscience.org/?s=epigen...

MitoSENS:
https://www.leafscience.org/?s=MitoSENS

Boominathan, A., Vanhoozer, S., Basisty, N., Powers, K., Crampton, A. L., Wang, X., ... & O'Connor, M. S. (2016). Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant. Nucleic acids research, 44(19), 9342-9357. (Also here: https://www.ncbi.nlm.nih.gov/pmc/arti...)

Senolytics:
https://www.leafscience.org/?s=senoly...

https://www.leafscience.org/aggregato...

The thymus and thymic regeneration:
https://www.leafscience.org/?s=thymus...

https://www.leafscience.org/understan...

https://www.leafscience.org/rejuvenat...

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#LifeExtension #Aging #LifeExtensionHistory #LifeXtenShow #X10 #LeonardHayflick #ElizabethBlackburn #Rejuvenation #BuckInstituteForResearchOnAging #AubreyDeGrey #MethuselahFoundation #ElieMetchnikoff

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