Skin Cancer | Clinical Medicine

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Ninja Nerds!
In this lecture, Professor Zach Murphy presents a comprehensive and high-yield breakdown of Skin Cancer, guiding you through the core concepts that every medical student and healthcare professional must understand when approaching malignant and premalignant conditions of the skin. This session provides a clear and structured framework to help you master the epidemiology, pathophysiology, clinical features, and management of the major skin cancers encountered on exams and in clinical practice.

We begin by reviewing the fundamental biology of the skin and the cellular origins of basal cell cancer, squamous cell cancer, and melanoma. Zach discusses the major risk factors that contribute to malignant transformation, including ultraviolet exposure, genetic predispositions, and environmental influences. You will learn how these factors drive specific molecular changes and how those changes translate into the characteristic appearance and behavior of each cancer type.

The lecture then transitions into detailed discussions on basal cell cancer and squamous cell cancer, highlighting the hallmark clinical findings, growth patterns, common locations, and key differences in local invasion and metastatic potential. Zach explains the classic features of actinic keratosis and its role as a precursor to squamous cell carcinoma, as well as the critical diagnostic cues that help distinguish non-melanoma skin cancers from benign lesions.

We continue with an in-depth exploration of melanoma, including its major histologic subtypes, the ABCDE criteria, patterns of radial and vertical growth, and the prognostic significance of Breslow depth. You will also learn how to identify worrisome lesion changes, recognize common exam scenarios, and approach melanoma staging and treatment using clinical reasoning.

Enjoy the lecture, and please support us below!

Table of Contents:
0:00 Lab
0:40 Pathophysiology of Skin Cancer
24:35 Classic Findings of Skin Cancer
41:25 Complications of Skin Cancer
49:37 Diagnostic Approach to Skin Cancer
57:21 Treatment of Basal Cell Carcinoma
1:00:49 Treatment of Squamous Cell Carcinoma
1:02:51 Treatment of Melanoma
1:07:15 Comment, Like, SUBSCRIBE!

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