Direct Thrombin Inhibitors and Factor Xa Inhibitors (DOACs) - Pharmacology - Hematology

Описание: Direct Thrombin Inhibitors and Factor Xa Inhibitors | Pharmacology | Hematology. Direct-Acting Oral Anticoagulants (DOACs).

Warfarin (anticoaulant) | Hematology & Pharmacology. Warfarin is an anticoagulant that inhibits the epoxide reductase enzyme which prevents the activation of vitamin K. Therefore, Warfarin inhibits the gamma carboxylation (gamma-glutamyl carboxylase) of the coagulation factors II, VII, IX, IX (2,7,9,10) as well as Protein C, Protein S, and Protein Z.


Heparin is an anticoagulant that stimulates antithrombin III (ATIII) which then inhibits coagulation factors VII, IX, X, XI, XII, as well as thrombin. This leads to prevention of thrombus formation (anticoagulation)...Heparin is used for ICU anticoagulation...Adverse effects of heparin includes bleeding, Heparin-induced thrombocytopenia (HIT), and osteoporosis.

Anticoaulants are chemicals that inhibit blood coagulation (secondary hemostasis).

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Vitamin K Deficiency | Hemorrhagic Disease of the Newborn or Vitamin K dependent bleeding (VKDB) is a bleeding disorder that occurs due to deficiency of vitamin K.
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Coagulation Tests (PT, aPTT, TT, Fibrinogen, Mixing Studies,..etc).
The coagulation factors are divided into 3 coagulation groups | Fibrinogen group, Prothrombin group, and Contact Group..

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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).

Bleeding 🩸 time (BT) is another test for platelet function.

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