Ictal Cinema - Visualizing Real Seizure Activity in the Human Brain

Описание: UCSF Epilepsy Ictal Cinema
This video shows the "Ictal Cinema" technology (a.k.a. OPSCEA: Omni-planar and Surface Casting of Epileptiform Activity) developed by the UCSF Epilepsy Center. It converts the usual complex recordings of hundreds of "traced-based" brain waves that doctors see (on the right) into an intuitive heatmap projected on the patient's own 3D reconstructed brain (right hemisphere of a patient's brain show at left). Each trace (line) on the right shows continuous measurement of brainwave voltage from a single intracranial electrode (black dots in the brain view). The seizure intensity is calculated automatically from the traces (specifically, from the grey window at the arrow) and converted into color intensity using a normalized "line length" algorithm. This simplified method reveals how seizure activity moves in space and time. The technology also uses "slice views" (example shown halfway through the video) so that activity from electrodes deep in the brain can be seen in addition to those on the brain surface. This seizure is driven by an "hotspot" in the medial temporal lobe (toward the bottom on the inner side), which generates bursts that rapidly propagate up to the front and top of the brain (frontal lobe) and then quickly move toward the back of the brain (parietal lobe). The slice view helps reveal and confirm this propagation path along the deeper electrodes in more detail.
See the paper: Kleen et al. (2021), "Accuracy of omni-planar and surface casting of epileptiform activity for intracranial seizure localization" (Epilepsia. https://doi.org/10.1111/epi.16841).