The Binding of Isaac | Daily Run 16th Feb 2026 (Rank: 2️⃣🥈)

Описание: Goal: Cain vs. ??? [Hard Difficulty]
Spiciest Stuff: Undefined (w/Vibrant Bulb), Brimstone (w/Mom's Knife), The Mark, Dark Bum, Scorpio, Lusty Blood
Transformations: Conjoined

The second run of February for Cain, but his first non-curated.

It's a Brimstone and Mom's Knife run! Early Brim and the knife appears a little later but this is a free win.

Even with just Brimstone, getting to Boss Rush should be a cakewalk.
Poison lasering through the bosses on spawn caused them a lot of trouble. Easy.

Had to skip a few rooms across the Womb floors to get to Hush though.
I used a Magician card I was saving for Boss Rush but forgot to use (🤦‍♂️) but it made the poison knife storm extra potent for a very quick Hush kill.

Another day, another Dark Bum appearance, HP is no object.
Sigil of Baphomet dropped from Lil Chest in Boss Rush if you need some extra defence.

An exceptionally strong build from very early on. The only reason it feels like Hard Mode is the larger floors.

Best of luck!

Fun rating: ⭐⭐⭐⭐⭐

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