SIM XL v1.1: a powerful and user-friendly tool for peptide cross-linking analysis
Автор: Diogo Borges
Загружено: 2015-10-29
Просмотров: 1527
Описание: State of the art structural mass spectrometry based proteomics is often accomplished by using cross-linkers to covalently bind two or more reactive groups. This strategy is complementary to classical structural biology and therefore broadens the toolset for analyzing protein and protein-protein complex structures. One of the greatest challenges in identifying cross-linked peptides in complex protein mixtures is computationally dealing with the large search space which grows exponentially with each peptide included in the sequence database. Spectrum Identification Machine for Cross-Linked Peptides (SIM-XL) is an algorithm to deal with this problem. It capitalizes on experimental features that allow us to effectively address the massive combinatorial problem at hand. SIM-XL is recommended for dealing with the studies of protein-structure and protein-protein-interaction in either simple or complex protein mixtures. Download at http://patternlabforproteomics.org/si...
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