SynGAP modulates the body's biological clock: What SYNGAP1 mice can tell us about light & sleep 🐭😴

Описание: ► Learn more about SynGAP research at: https://www.syngapresearchfund.org

Dr. Sydney Aten obtained her PhD in Neuroscience from Ohio State University. She worked as a doctoral student in the lab of Dr. Min Zhou researching basic astrocyte physiology and the effects of chronic stress on astrocyte gap junction coupling. Related to SYNGAP, she is the first author on an important paper “SynGAP is expressed in the murine suprachiasmatic nucleus and regulated circadian-gated locomotor activity and light entrainment capacity”

Her interest is researching the molecular/cellular underpinnings of circadian clock entrainment, cognition, and mood.

She is also an aspiring astronaut!

Chapters:
00:00​ Welcome and introduction to the work of Dr Sydney Aten
03:21 Outline
04:21 SYNGAP1 haploinsufficiency leads to sleep abnormalities
07:30 What might be contributing to these sleep disturbances?
10:41 SYNGAP1 and sleep homeostasis - potential mechanism
13:15 Might there also be a circadian component that involves SYNGAP1?
16:10 Background: ERK/MAPK Signaling Pathway
19:52 SynGAP and the ERK/MAPK Pathway
26:00 pSynGAP SCN expression is rhythmic and light-inducible
28:13 Does SynGAP dysfunction lead to alterations in circadian timing?
33:47 Het mice show increased light-evoked ERK activation and behavioral phase shifting capacity
37:02 Key Conclusions
41:23 Considerations
46:17 Q&A

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