Structural Heterogeneity in Focus: Preparing for Cryo-EM Success
Автор: NanoImaging Services
Загружено: 2026-01-30
Просмотров: 127
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Want to understand how cryo-EM can reveal epitope-paratope interactions—even in samples with significant conformational dynamics?
Dr. Kenny Kang, Senior Scientist at NanoImaging Services, demonstrates how cryo-EM can visualize discrete states within conformationally flexible samples, using the SARS-CoV-2 spike protein as a case study. This work shows how states that typically produce blurred or unresolved maps can instead be captured and distinguished. You’ll see how cryo-EM enables direct observation of receptor-binding domain motion and overcomes limitations inherent to static structural techniques.
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