PEARL — Testing Rapamycin for Healthy Life Extension In Humans | Lifespan.io Crowdfunding Campaign

Описание: The medicine Rapamycin has been shown to extend healthspan in all organisms it has been tested on for decades, and yet there's been no trial sufficiently demonstrating safety and proper dosing in humans. Help us change this - support our Lifespan.io campaign! https://www.lifespan.io/PEARL

PEARL Rapamycin Trial Description
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We will be conducting a large clinical trial named Participatory Evaluation (of) Aging (with) Rapamycin (for) Longevity Study, or PEARL, to find out. This will be the first study to see if Rapamycin works as well in humans as it does in mice (for longevity).

Rapamycin was the first molecule proven to extend the lifespan of a mammal/mouse, even when given late in life. It also has the potential to treat aging related diseases such as Alzheimer’s or heart disease, and not to mention, boost our immune system as well. It is by far the most studied longevity intervention after Calorie Restriction (CR).

Rapamycin works through the mTOR signaling pathway, one of the master regulators of cell metabolism and a key controller of autophagy (recycling in cells). Basically, it tells our cells to switch from growth to repair, and to clean out all the garbage. Not only that, but the quality of the proteins our cells produce increases, which means that there is less garbage in the first place. What all this amounts to is improved health and lengthened life for worms, flies and mice – now it’s our turn!

The PEARL trial will follow up to 200 participants over 12 months testing four different Rapamycin dosing regimens. It will be double-blind, randomized, placebo-controlled and registered with clinicaltrials.gov. The principal investigator is Dr. James P Watson at UCLA, who was also a PI for the famous TRIIM trial. To ensure safety the participants’ blood will be regularly monitored and side effects noted.

PEARL is being run by the team of AgelessRx: Anar Isman and Dr. Sajad Zalzala: with Dr. James Watson of UCLA as principle investigator.

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Kurzgesagt:    • How to Cure Aging – During Your Lifetime?  
Life Noggin:    • Live 200 Years? This Is How You Could Do It.  

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Age-related diseases, such as Alzheimer's, heart disease, and cancer, are some of the worst drains on our society, both in terms of personal suffering and socio-economic effects. One of the reasons why our work is so important is that, historically, research aimed at tackling these diseases has been focused at the end stages of such maladies, when it is too late to reverse the damage that has been done. A good analogy is a tree: what makes more sense — spending a ton of money trying to cure a branch of a branch, or directing that focus to the trunk of the tree itself? Aging is the greatest risk factor for all of these major diseases, and in many cases, it is ultimately the primary cause. While it may seem hard to believe, biological science has finally progressed enough to begin targeting the root mechanisms of aging, and — thanks to the efforts of the world-renowned researchers and labs we work with, such as Drs. David Sinclair, George Church, and Aubrey de Grey — is beginning to bring aging, and therefore these diseases, under medical control. Everything we've done thus far, and everything we will do in the future, is thanks to your support, and that is why we are asking you to stand with us - to be a Lifespan Hero and help us improve the lives of not just ourselves and our family members, but everyone in the entire world.

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Join us, and together, we can overcome diseases like Alzheimer's, heart disease, and cancer by addressing their shared source: the aging processes themselves.

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