MIT CompBio Lecture 09 - Three Dimensional Genome
Автор: Manolis Kellis
Загружено: 2018-10-05
Просмотров: 7300
Описание:
MIT Computational Biology: Genomes, Networks, Evolution, Health
Prof. Manolis Kellis
http://compbio.mit.edu/6.047/
Fall 2018
Lecture 09 - Three Dimensional Genome
1. Methods for studying nuclear genome organization
Measuring locus-landmark interactions: ChIP, DamID
Measuring locus-locus interactions: 3C, 4C, 5C, Hi-C, ChIA-PET
2. Processing and normalization of Hi-C datasets
Correcting for biases and issues with Hi-C data
Normalization, sources of bias and bias correction
3. Interpretation of data and functional characterization
Lamina Associated Domains (LADs)
Topologically Associated Domains (TADs) and other compartments
4. Conservation of nuclear genome organization
Across species, across cell types
Sequence basis for conservation?
5. Towards a mechanistic understanding
Nuclear genome organization through the (single) cell cycle
(Limitations of) 3D modeling of nuclear genome organization
Loop extrusion as a potential mechanism for nuclear organization
Slides for Lecture 9:
https://stellar.mit.edu/S/course/6/fa...
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